OUR PARTNERS

   

         

      

  

 

       

 

 

 

 

 

 

 

CONTACT US

PEPTIDES NPCRIZ STORE
HUNGARY
UKRAINE
shop(a)npcriz.co

DISCOUNTS

our price 85,00 EUR (99,45 USD)
In Stock
our price 21,00 EUR (24,57 USD)
In Stock
our price 85,00 EUR (99,45 USD)
In Stock

NEW ARTICLES

arr32020 Viorgons. Prevention and assistance with various diseases. Strokes, heart attacks, traumatic brain injuries (operations).If there is a violation of the... arr32019 Oligopeptides and the nuances of their use This article is devoted to oligopeptides and the nuances of their use. Very often, talking about... arr32019 Healthy Liver - Healthy Skin! You can ask banal questions:How often do you wash your face?Do you brush your teeth?Do you clean... arr32019 Peptides NPCRIZ: Effective Protection of the Liver and Pancreas    The human body works as a single, well-coordinated mechanism and any failure in the work of... arr32019 Anti-age complex NB Anti-AGE Complex NB: The Secret of Stellar Excellence   Friends! It is time for a pleasant... arr32019 NEW PRODUCT Nose Balms "RINOLAX" Nose Balms "RINOLAX"DESCRIPTIONBalsams "Cleansing" and "Regenerating" - innovative, effective... arr32018 Cardiovascular disease prevention September 29, worldwide, at the initiative of the World Heart Federation, with the support of many... arr32018 Previn and Peptide complex 19 - a complex for the prevention of cardiovascular diseases September 29 all over the world, at the initiative of the World Heart Federation, with the support... arr32018 Antitumor effect of peptides The modern period of development of medicine is characterized by significant achievements in the... arr32018 Trap for fat Customer feedback:"I learned about it from my brother, who lost about 7 kg with his help. His... arr32018 Zhenoluten and Endoluten - solving problems related to menopause Want to delay the onset of menopause and stay healthy for a long time? Do not neglect the latest... arr32018 Cytamins is a novel dietary supplements. Cytamins - are products for people who care about their health and appearance. Preservation of... arr32018 Why does not standard cosmetics help? Why does not standard cosmetics help?peptide cosmetics, peptides Any good, modern cream can... arr32018 How do peptides work for weight loss? Peptides are chains of proteins responsible for metabolic processes in our body, as well as for... arr32018 Create protection for immunityCreate protection for immunity   And although the window is still September with a gentle sun and... arr32018 Which peptides are the most important President of the Gerontological Society at the Russian Academy of Sciences, Doctor of Medical... arr32018 Revilab Peptide ML - a series of multifunctional AGE-protectors !  Youth and beauty have long been synonymous with the word "health". Today, many of us are... arr32017 Recovering the liver with peptides is extremely important in the fallRecovering the liver with peptides is extremely important in the fall. The aggravation of many... arr32017 Endoluten - treatment of human reproductive disordersRelationship between epiphysis cycles and human ageepiphysis The epiphysis (pineal body) is a small... arr32017 NEW Cosmetics RevilabNEW Cosmetics Revilab The company NPCRIZ constantly cares about its customers and fans of products.... arr32017 Revilab peptide SL ‒ innovation of the future!Modern consumers live in an accelerated pace, value their time and strive for a quick result. Each... arr32017 I was returned to life by peptides NPCRIZ "My name is Zhibek Aidarbekova. I am 58 years old. I live in Almaty, I am a retired police major,... arr32017 Nomination for the Nobel PrizeProfessor Chavinson wanted to extend the life of his parents. Russian Professor Vladimir Havinson... arr32017 Regenart: Joints under protection Diseases of the spine and joints are becoming an increasingly urgent problem in modern society. In... arr32017 What is diabetes?Diabetes and peptides, diabetes treatment. Diabetes is a chronic disease associated with a... arr32017 Why the standard of cosmetics does not help? Any good, modern cream can improve the appearance of the skin because it has moisturizing,... arr32017 The difference between peptides like GHRP-2 and GHRP-6 from Chavinson peptidesAll bodybuilders must read this article!Ghrp peptides A few years ago the world of bodybuilding was... arr32017 Peptides in bodybuildingHormones take a leading position among drugs to increase muscle mass, burn fat and increase stamina.... arr32017 Antitumor activity of peptides. Peptides and cancerThe modern period of development of medicine is characterized by significant achievements in the... arr32017 About therapy of patients with chronic prostatitisIn both scientific and popular editions devoted to the problem of chronic prostatitis, there is a... arr32017 So what is the uniqueness of the peptides NPCRIZ Today, scientists know that aging and disease of an organism begins at the moment when stops... arr32017 A cure for old ageAging is a biological process which in contrast to the time influenced. People have always tried to... arr32017 Research peptides NPCRIZThe deterioration of the peptide Bioregulation in the body reduces its resistance to destabilizing... arr32017 The secret of life is in the nano-peptidesGerontologists Experts say that in homo sapiens, like biological species, the life limit is 110-120... arr32017 The peptides NPCRIZ in sports and bodybuildingNatural peptides of SPB of Institute of Bioregulation and gerontology are widely used in... arr32016 PEPTIDE geroprotectors - prevention of agingSt. Petersburg Institute of Bio-regulation and Gerontology,Saint Petersburg A typical sign of aging... arr32016 A model of complementary interaction of short peptides with the DNA double helixComparison of the spatial arrangement of functional groups of the nucleic bases on the surface of... arr32016 Peptides in cosmeticsPeptides can include not only medicines, but also in other products. For example, Russian scientists... arr32016 Why is all shown interest in peptide bioregulators? The interest on the part of scientists, doctors, beauty industry professionals, and ordinary... arr32016 Peptides NPCRIZ for the prevention and treatment of Zika VirusIn today's time when the world is attacked by new diseases, such as Zik Virus , the NPCRIZ company... arr32016 Serum for skin around the eyes №5Serum for skin around the eyes №5 green BeautifeyeTM and horse chestnut seed extract are directed... arr32016 WHAT IS REVITALIZATION ?Revitalization is a new direction in medicine, designed to facilitate the restoration, or rather,... arr32016 New products 2016  The range of natural peptide bioregulators added another novelty - geroprotector " Bonomarlot... arr32015 NEW Citomax-GlandokortThe complex of peptide fractions obtained from adrenal young animals. The isolated peptides have a...

MOST POPULAR

our price 17,50 EUR (20,48 USD)
In Stock
our price 23,00 EUR (26,91 USD)
In Stock


2018 Antitumor effect of peptides

The modern period of development of medicine is characterized by significant achievements in the field of creating medicines based on peptides, studying their clinical effectiveness and substantiating the appropriateness of using various diseases and pathological conditions in complex therapy. The study of the mechanisms of action of peptides acquires special significance in connection with the development of biological therapy of tumors aimed at enhancing the protective functions of the organism.

          To evaluate the effect of natural and synthetic peptides on carcinogenesis, the effect of these peptide preparations on the growth of spontaneous, induced and transplanted tumors in experimental animals was studied.

          The results of the studies indicate that the peptides have a pronounced protective effect in experimental carcinogenesis and have a modulating effect on the immune and neuroendocrine systems of the body in the tumor process.

          The use of natural peptides in mice and rats contributed to a significant decrease in the frequency of development of spontaneous tumors by 1.5-2.5 times and an increase in the life span of animals by 30-40%. At the same time, there was also an increase in the indices of cellular immunity.

          When studying the effect of natural peptides on the carcinogenesis induced by radiation exposure, the inhibitory effect of drugs on the growth of tumors was clearly established. The number of rats that developed malignant tumors in the experimental group was 1.9-2.7 times less than in the control group. The median latent period of the onset of tumors in the group of rats receiving natural peptides was on average 2 months longer than in the controls.

          In irradiated mice treated with natural peptides, the incidence of all tumors was 28%, whereas in irradiated animals in control, this was 92%. The number of malignant tumors decreased with the administration of drugs 10 times.

          The effect of natural peptides on chemical carcinogenesis was investigated in the rat adenocarcinoma model of rats induced by the administration of 7,12-dimethylbenz (a) anthracene. In control animals under the influence of a carcinogen, adenocarcinomas of the breast developed in 80% of cases, and when the peptides were introduced, only in 25%. At the same time, the multiplicity of adenocarcinoma decreased 3 times.

          Important results for the evaluation of antimutagenic and anticarcinogenic properties of peptide preparations have the results obtained in the study of their effect on transplacental carcinogenesis in rats that were exposed to nitrosoethylurea during pregnancy. As is known, when nitrosoethylurea is administered to female rats, glial tumors of the central nervous system and peripheral nerve nerves develop at a high frequency in the offspring. The introduction of natural peptides promoted an increase in the latent period of tumor development by an average of 2 months, a decrease in the index of tumor multiplicity by 1.4 times, a decrease in the frequency of neoplasms of the spinal cord and kidneys, and an increase in the life span of animals.

          The data that natural peptides cause inhibition of carcinogenesis and an increase in the life span of laboratory animals have served as the basis for studying the effect of synthetic peptides (analogues of endogenous) on these parameters.

          The use of di- and tetrapeptides exerted a depressing effect on spontaneous carcinogenesis in mice, which was expressed in a 1.5-fold decrease in the incidence of all tumors and in 1.9 times the multiplicity of tumors. The survival dynamics in all the study groups of animals did not differ significantly until the age of 22 months, after which a clear decrease in mortality was observed under the influence of peptides.

          When the dipeptide was administered to rats exposed to radioactive radiation from a mixture of 90Sr and 137Cs, inhibition of the development of malignant tumors was observed, in particular, a reduction in the incidence of adenocarcinoma of the mammary gland. In this case, an increase in the maximum life expectancy by 4.6 months was observed in comparison with the animals in the control group.

          It was found that the tetrapeptide suppressed the growth of colon tumors induced by 1,2-dimethylhydrazine. The effect of this drug was expressed in reducing the multiplicity of tumors and their size.

          When studying the effect of synthetic peptides on the occurrence and development of cancer of the bladder induced by the carcinogen of the selective action of N-butyl-N- (4-hydroxybutyl) nitrosamine, it was found that 56% of the animals developed the tumor dipeptide, while in the control group - in 75.5% of cases. With the action of the drug, there was a 2-fold decrease in the development of preneoplastic and early neoplastic changes in the mucous membrane of the bladder and a significant inhibition of carcinogenesis. The action of the dipeptide led to the inhibition of both the initiation of carcinogenesis and the promotion, i. E. realization of the tumor process.

         

Synthetic di- and tetrapeptides when administered to animals with transplanted hepatoma had a significant inhibitory effect at an early stage after inoculation of tumor cells. When studying the effect of peptides on the growth of the tumor, ACATOL, their inhibitory effect was also established. The use of synthetic peptides during the latent period led to a significant slowing of the growth rate of the transplanted sarcoma M-1. The inhibitory effect was manifested 2 weeks after the termination of the course of the peptide administration and was maintained for the entire observation period. In addition, it was found that after the use of peptides, the level of apoptotic death of tumor cells increased.

          The effect of synthetic peptides on carcinogenesis was examined in females of transgenic mice bearing the breast cancer gene. The number of animals in which mammary tumors did not develop, in the group receiving tetrapeptide, was 1.6 times more than in the control. The maximum size of mammary adenocarcinoma in mice treated with this peptide was 33% less than in controls. The expression of the oncogene in mammary tumors of mice treated with tetrapeptide was reduced 3.7-fold compared to the same index in tumors of control mice.

          Experimental studies of the antitumor effect of natural and synthetic peptides testify to the effect of these drugs on mechanisms of carcinogenesis and the prospects of their use in cancer patients.

          Due to the fact that natural peptides contribute to the restoration of cellular immunity and hormonal regulation, and also have an antitumor effect, these drugs were used in cancer patients mainly with hormone-dependent forms of tumors (breast, body or cervical cancer, ovaries and other localization). All patients underwent histological verification of the tumor process. Most subjects were subjected to a combined or complex treatment.

          Natural peptides were used in patients with breast cancer II-III stage on the background of radiation therapy. The drugs were prescribed according to various schemes: after the end of radiotherapy, in the middle of the course and in the last 5-10 days of preoperative radiotherapy. In some patients, peptides were applied in the long term after the radiation therapy (after 2-6 months) due to the development of persistent leukopenia and lymphopenia, which can not be corrected by other drugs. The introduction of peptides to patients with breast cancer promoted an increase in the number of lymphocytes and T-lymphocytes in the blood. In addition, in patients after immunocorrection, the functional activity of T cells was improved and the intensity of cellular immunity responses was restored. The introduction of drugs to patients in the long term after irradiation caused an increase in the number of leukocytes in the blood. The parameters of cellular immunity after the use of drugs have almost normalized.

          In clinical studies conducted in patients with cervical cancer receiving natural peptides, there was an increase in the number and functional activity of T lymphocytes in peripheral blood. The administration of drugs to patients with cervical cancer who received radiation treatment or chemotherapy had a pronounced protective effect on hemopoiesis, prevented the development of leukopenia, thrombocytopenia, as well as inflammatory postoperative complications.

          The results of the studies testify to the prospects of using combined progestin therapy and immunotherapy in primary patients with endometrial cancer. The study of the effect of natural peptides on immunological parameters in patients with endometrial cancer after preoperative hormone therapy showed that treatment leads to a significant increase in the absolute number of lymphocytes and T-lymphocytes. Simultaneously, restoration of the functional activity of T-lymphocytes was observed.

          The results of an experimental study of the effect of synthetic peptides on the growth of spontaneous, induced and transplanted tumors also served as the basis for the use of these drugs in cancer patients.

          The use of dipeptide in patients with colorectal cancer over the age of 50 years with surgical and complex treatment, as well as its use against the background of the generalization of the tumor process that has developed after previous radical treatment, contributes to the normalization of the immune status of patients, reducing the number of side effects and toxic effects of chemotherapy. The use of 3 courses of the drug in patients of this category in the first 6 months after radical treatment caused a significant decrease in the incidence of relapse and generalization of the tumor in the next 2 years.
Dipeptide was used in patients with breast cancer against high-dose polychemotherapy. During the follow-up (22 months) positive results were observed in 100% of patients, no relapses and metastases were detected. At the same time, during this period in the control group with the tradition

 

NWY2YmRhM