DHL worldwide shipping


our price 103,00 EUR (101,97 USD)
In Stock
our price 175,00 EUR (173,25 USD)
Out of Stock
our price 58,00 EUR (57,42 USD)
In Stock


arr32021 Respiro 180 Peptides / Respiro 3 Linguals. Taking care of the respiratory system With the onset of cold weather, we are susceptible to exacerbation of... arr32021 How to preserve your vision Cheerfulness, activity, dynamism and richness with life are indispensable attributes of the... arr32021 Changes in human sperm motility characteristics in the presence of Viorgon-18  Viorgon-18 V.V. Evdokimov1 , Е.А. Efremov1 , P.А. Elistratov2 , I.А. Yamskov2 , А.F.... arr32021 Viophtans: Structural aspects and chaperone activity ... arr32020 Viorgons. Prevention and assistance with various diseases. Strokes, heart attacks, traumatic brain injuries (operations).If there is a violation of the... arr32019 Oligopeptides and the nuances of their use This article is devoted to oligopeptides and the nuances of their use. Very often, talking about... arr32019 Healthy Liver - Healthy Skin! You can ask banal questions:How often do you wash your face?Do you brush your teeth?Do you clean... arr32019 Peptides NPCRIZ: Effective Protection of the Liver and Pancreas    The human body works as a single, well-coordinated mechanism and any failure in the work of... arr32019 Anti-age complex NB Anti-AGE Complex NB: The Secret of Stellar Excellence   Friends! It is time for a pleasant... arr32019 NEW PRODUCT Nose Balms "RINOLAX" Nose Balms "RINOLAX"DESCRIPTIONBalsams "Cleansing" and "Regenerating" - innovative, effective... arr32018 Cardiovascular disease prevention September 29, worldwide, at the initiative of the World Heart Federation, with the support of many... arr32018 Previn and Peptide complex 19 - a complex for the prevention of cardiovascular diseases September 29 all over the world, at the initiative of the World Heart Federation, with the support... arr32018 Antitumor effect of peptides The modern period of development of medicine is characterized by significant achievements in the... arr32018 Trap for fat Customer feedback:"I learned about it from my brother, who lost about 7 kg with his help. His... arr32018 Zhenoluten and Endoluten - solving problems related to menopause Want to delay the onset of menopause and stay healthy for a long time? Do not neglect the latest... arr32018 Cytamins is a novel dietary supplements. Cytamins - are products for people who care about their health and appearance. Preservation of... arr32018 Why does not standard cosmetics help? Why does not standard cosmetics help?peptide cosmetics, peptides Any good, modern cream can... arr32018 How do peptides work for weight loss? Peptides are chains of proteins responsible for metabolic processes in our body, as well as for... arr32018 Create protection for immunityCreate protection for immunity   And although the window is still September with a gentle sun and... arr32018 Which peptides are the most important President of the Gerontological Society at the Russian Academy of Sciences, Doctor of Medical... arr32018 Revilab Peptide ML - a series of multifunctional AGE-protectors !  Youth and beauty have long been synonymous with the word "health". Today, many of us are... arr32017 Recovering the liver with peptides is extremely important in the fallRecovering the liver with peptides is extremely important in the fall. The aggravation of many... arr32017 Endoluten - treatment of human reproductive disordersRelationship between epiphysis cycles and human ageepiphysis The epiphysis (pineal body) is a small... arr32017 NEW Cosmetics RevilabNEW Cosmetics Revilab The company NPCRIZ constantly cares about its customers and fans of products.... arr32017 Revilab peptide SL ‒ innovation of the future!Modern consumers live in an accelerated pace, value their time and strive for a quick result. Each... arr32017 I was returned to life by peptides NPCRIZ "My name is Zhibek Aidarbekova. I am 58 years old. I live in Almaty, I am a retired police major,... arr32017 Nomination for the Nobel PrizeProfessor Chavinson wanted to extend the life of his parents. Russian Professor Vladimir Havinson... arr32017 Regenart: Joints under protection Diseases of the spine and joints are becoming an increasingly urgent problem in modern society. In... arr32017 What is diabetes?Diabetes and peptides, diabetes treatment. Diabetes is a chronic disease associated with a... arr32017 Why the standard of cosmetics does not help? Any good, modern cream can improve the appearance of the skin because it has moisturizing,... arr32017 The difference between peptides like GHRP-2 and GHRP-6 from Chavinson peptidesAll bodybuilders must read this article!Ghrp peptides A few years ago the world of bodybuilding was... arr32017 Peptides in bodybuildingHormones take a leading position among drugs to increase muscle mass, burn fat and increase stamina.... arr32017 Antitumor activity of peptides. Peptides and cancerThe modern period of development of medicine is characterized by significant achievements in the... arr32017 About therapy of patients with chronic prostatitisIn both scientific and popular editions devoted to the problem of chronic prostatitis, there is a... arr32017 So what is the uniqueness of the peptides NPCRIZ Today, scientists know that aging and disease of an organism begins at the moment when stops... arr32017 A cure for old ageAging is a biological process which in contrast to the time influenced. People have always tried to... arr32017 Research peptides NPCRIZThe deterioration of the peptide Bioregulation in the body reduces its resistance to destabilizing... arr32017 The secret of life is in the nano-peptidesGerontologists Experts say that in homo sapiens, like biological species, the life limit is 110-120... arr32017 The peptides NPCRIZ in sports and bodybuildingNatural peptides of SPB of Institute of Bioregulation and gerontology are widely used in... arr32016 PEPTIDE geroprotectors - prevention of agingSt. Petersburg Institute of Bio-regulation and Gerontology,Saint Petersburg A typical sign of aging... arr32016 A model of complementary interaction of short peptides with the DNA double helixComparison of the spatial arrangement of functional groups of the nucleic bases on the surface of... arr32016 Peptides in cosmeticsPeptides can include not only medicines, but also in other products. For example, Russian scientists... arr32016 Why is all shown interest in peptide bioregulators? The interest on the part of scientists, doctors, beauty industry professionals, and ordinary... arr32016 Peptides NPCRIZ for the prevention and treatment of Zika VirusIn today's time when the world is attacked by new diseases, such as Zik Virus , the NPCRIZ company... arr32016 Serum for skin around the eyes №5Serum for skin around the eyes №5 green BeautifeyeTM and horse chestnut seed extract are directed... arr32016 WHAT IS REVITALIZATION ?Revitalization is a new direction in medicine, designed to facilitate the restoration, or rather,... arr32016 New products 2016  The range of natural peptide bioregulators added another novelty - geroprotector " Bonomarlot... arr32015 NEW Citomax-GlandokortThe complex of peptide fractions obtained from adrenal young animals. The isolated peptides have a...


our price 21,84 EUR (21,62 USD)
Out of Stock
our price 32,00 EUR (31,68 USD)
In Stock
our price 94,00 EUR (93,06 USD)
In Stock

2017 Antitumor activity of peptides. Peptides and cancer

The modern period of development of medicine is characterized by significant achievements in the field of creation of medicines based on peptides, to study their clinical efficacy and rationale for use in complex therapy of various diseases and pathological conditions. Investigation of the mechanisms of action of the peptides is of particular importance in connection with the development of biological tumor therapy aimed at enhancing immune function.
To assess the influence of natural and synthetic peptides on carcinogenesis studied the effect of these peptide drugs on the growth of spontaneous, induced, and transplantable tumors in experimental animals.
The research results indicate that peptides have a pronounced protective effect in experimental carcinogenesis and have a modulating effect on the immune and neuroendocrine systems of the body involved in the tumor process.
The use of natural peptides in mice and rats has contributed to a significant decrease in the incidence of spontaneous tumors in 1.5-2.5 times and increase the life expectancy of animals by 30-40%. It was also observed the increase of cellular immunity.
In studying the effect of natural peptide induced radiation effects carcinogenesis was found distinct inhibitory effect of drugs on tumor growth. The number of rats who developed malignant tumors in the experimental group was 1.9-2.7 times less than in control. The average latent period of tumours in the group of rats receiving the natural peptides were on average 2 months more compared to the control.
In irradiated mice, which were injected with natural peptides, the frequency of all tumors was 28 %, whereas in the irradiated animals in control the figure was 92 %. The number of malignant tumours was reduced by administration of drugs 10 times.
The influence of natural peptides for chemical carcinogenesis was studied on the model of adenocarcinomas of the mammary gland of rats induced by 7,12 introduction–dimethylbenz(a)anthracene. In the control animals under effect of the carcinogen of adenocarcinoma of the breast developed in 80% of cases, and the introduction of the peptide only in 25 %. Up to 3 times decreased the multiplicity of occurrence of adenocarcinomas.
Important to assess the antimutagenic and anticarcinogenic properties of peptide drugs are the results obtained from the study of their impact on transplacental carcinogenesis in rats, which were exposed during pregnancy effects of nitrozomocevina. As you know, with the introduction of nitrozomocevina rats–females in offspring with high frequency develop glial tumors of the Central nervous system and neuromas of the peripheral nerves. Introduction natural peptides contributed to the increase in the latent period of tumor development by an average of 2 months, the index decreased the multiplicity of tumors was 1.4 times, reducing the frequency of tumors of the spinal cord and kidneys and increase lifespan of animals.
Evidence that natural peptides cause inhibition of carcinogenesis and increase the lifetimes of laboratory animals, was the basis to study the effect of synthetic peptides (analogs endogenous) of these indicators.
The use of di - and tetrapeptides had a dampening effect on spontaneous carcinogenesis in mice, which was reflected in the decrease in 1.5 times the incidence of all tumors and 1.9 times the multiplicity of tumors. The dynamics of survival in all studied groups of animals were not significantly different until the age of 22 months, and then observed a distinct decrease of mortality under the influence of the peptides.
With the introduction of dipeptide rats exposed to radiation from a mixture of 90Sr and 137Cs was observed in the inhibition of malignant tumors, in particular, the reduction in the incidence of adenocarcinomas of the mammary gland. It was noted the increase of maximum life span by 4.6 months compared to control group animals.
It is established that the tetrapeptide inhibited the growth of colon tumors induced by 1,2–dimethylhydrazine. The effect of this drug was reflected in a decrease in the multiplicity of tumors and their size.
In studying the effect of synthetic peptides on the occurrence and development of bladder cancer induced by carcinogen selective action of N-butyl-N-(4-hydroxybutyl)nitrosamines, found that the introduction of dipeptide tumor appeared in 56% of animals, while in the control group at 75.5% of cases. Under the action of the drug is marked reduction in 2 times the development preneoplastic and early neoplastic changes in the bladder mucosa and significant inhibition of carcinogenesis. The effect of the dipeptide resulted in inhibition as the process of initiation of carcinogenesis, and promotion, i.e. the implementation of the neoplastic process.
Synthetic di - and tetrapeptide when administered to animals with transplanted hepatomas provided reliable inhibitory effect in the early stages after inoculation of tumor cells. In the study of the influence of the peptide on tumor growth ACETOL was established also their inhibitory effect. The use of synthetic peptides for the latent period led to a significant slowdown in the growth of transplantable sarcoma M-1. The inhibitory effect was evident 2 weeks after completion of the injection of peptide, and persisted throughout the observation period. In addition, it was found that after application of the peptides increased the level of apoptotic death of tumor cells.
The effect of synthetic peptides on carcinogenesis were examined in female transgenic mice carrying gene for breast cancer. The number of animals whose breast tumor did not develop in the group that received the tetrapeptide, was 1.6 times more than in controls. The maximum size of adenocarcinomas of the mammary gland in mice treated with this peptide, was 33% less than in control. Expression of the oncogene in mammary tumors of mice that received the tetrapeptide, were reduced by 3.7 times in comparison with the same indicator in tumors of control mice.
Experimental study of antitumor action of natural and synthetic peptides indicate the influence of these drugs on the mechanisms of carcinogenesis and prospects for their application in cancer patients.
Due to the fact that the natural peptides contribute to the restoration of cellular immunity and hormonal regulation, as well as have anti-tumor activity, these drugs used in cancer patients mainly with hormone-dependent tumours (breast cancer, of the body or the cervix of the uterus, ovaries and other sites). All patients had histological verification of tumor process. The majority of the subjects were subjected to the combined or complex treatment.
The natural peptides used in patients with breast cancer stage II-III, during radiation therapy. Drugs were administered on different circuits: after completion of radiotherapy, in the middle of the course and in the last 5-10 days of preoperative radiotherapy. Some patients peptides used in the remote terms after radiation therapy (after 2-6 months) in connection with the development of persistent leukopenia and lymphopenia that are not amenable to correction with other drugs. Introduction peptides with cancer of the breast contributed to the increase in the number of lymphocytes and T-lymphocytes in the blood. In addition, in patients after immune improved functional activity of T-cells and recovered the intensity of reactions of cellular immunity. Administration of drugs to patients in the remote terms after irradiation caused an increase in the number of leukocytes in the blood. Indicators of cellular immunity after administration of preparations is almost normal.
In clinical studies conducted in patients with cervical cancer treated with natural peptides marked increase in the number and functional activity of T-lymphocytes in the peripheral blood. Prescriptions for patients with cervical cancer who received radiation therapy or chemotherapy, had a pronounced protective effect on haematopoiesis, warned the development of leukopenia, thrombocytopenia, and inflammatory postoperative complications.
The research results indicate the prospects of application of combined projectnature and immunotherapy in patients with primary endometrial cancer. The study of the influence of natural peptides on immunological parameters in patients with endometrial cancer after preoperative course of hormone therapy showed that the treatment leads to a significant increase in the absolute number of lymphocytes and T-lymphocytes. Simultaneously, we observed recovery of the functional activity of T-lymphocytes.
The results of experimental study of influence of synthetic peptides on the growth of spontaneous, induced and transplanted tumors has also led to the use of these drugs in cancer patients.
Application of the dipeptide in patients with colorectal cancer aged over 50 years in surgical and complex treatment, and the use of it in the background of the generalization of cancer developed after the previously performed radical treatment helps to normalize the immune status of patients, reduce adverse and toxic effects of chemotherapy. Use 3 courses of the drug in patients of this category in the first 6 months after radical treatment caused a significant decrease in the incidence of relapses and generalization of the tumor in the next 2 years.

A dipeptide used in patients with breast cancer on the background of high-dose chemotherapy. In the process of observation (22 months) noted positive results in 100% of patients, there were recurrences and metastases. At the same time, during this period in the control group with traditional treatment regimens have to 35.2% of patients with the revealed distant metastases. The use of the drug has improved the tolerability of chemotherapy (decreased frequency of vomiting, nausea) were noted more rapid recovery of leukocyte count, lymphocytes of different subpopulations and platelets. Decreased length of stay of patients in hospital on average for eight days.
Ontomodificationdate properties of the dipeptide were evaluated in the complex treatment of patients with inoperable forms of cancer of the breast and ovaries. While all patients noted reduction of pain, restoration of appetite and weight gain.
A dipeptide used in patients with dysplasia or pre-invasive carcinoma of the cervix in the process of surgical conization of the cervix. In the study it was found that the drug helped restore the number of T-lymphocytes, phagocytosis, and a significant increase in the level of natural killer cells. 90% of the patients after treatment noted morphological signs of regeneration in the remote cone of the cervix. This was not observed amplification of the morphological signs of malignancy of the cervical epithelium, on the contrary, in many patients, the severity of the neoplastic transformation of cervical epithelium after treatment is reduced. The average time to the exclusion of burn eschar in patients who received the dipeptide was 5±1.6 days in patients of the control group and 11±2.0 days. The reduction in the time to rejection of scab was observed in 55% patients of the main group. Inflammatory complications (necrosis with purulent discharge) were noted in 10% of patients of the main group and 70% in the control group. Postoperative period with application of the dipeptide had fast loosening and rejection of the scab and the absence of pronounced necrosis in the area of the burn eschar. The average period of complete epithelialization of surgical wounds in patients of the main group was 29±2.4 days in patients of the control group and 48±7.2 days.
In conclusion, we must admit that the main focus of anticancer therapy is the destruction of tumor mass. However, the development of molecular genetic studies in recent years have opened a new intracellular interaction and communication of tumor cells with the microenvironment, immune and vascular system, with normal tissues. Prospects for application and further development of methods of biological therapy of cancer in the light of new scientific knowledge is no longer in doubt. Our clinical experience suggests that the use of peptides to patients regardless of the stage of the cancer and treatment not only enhances efficiency but also significantly improves the quality of life of this category of patients.