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2016 PEPTIDE geroprotectors - prevention of aging

St. Petersburg Institute of Bio-regulation and Gerontology,
Saint Petersburg

A typical sign of aging is a decrease in the body's ability to adapt, which is based on a natural decline in the function of cells, organs and systems. Among them, much attention of researchers attracted to arise in the process of aging changes in the basic systems of the body - the immune, cardiovascular, central nervous and endocrine systems. With aging in well-coordinated mechanism of interaction of various organs and systems there is a dissonance that leads to a weakening of control over the internal environment of the body, weakening of immunological reactivity and self-regulation [1].
It must be emphasized that the use of geriatric funds physiological stimulation of the body's aging scientifically proven modern ideas about the mechanisms of aging, which means that there is a fundamental opportunity to influence and control within certain limits, the process of human aging. The search for new effective means of influencing the aging body, finding the most efficient combinations of geriatric resources - an important task. In broad terms, gerontological research more clearly defined search tools that affect the underlying mechanisms of aging. [4] This approach is based on the existence in the body bioregulation systems acting through cellular mediators, which are peptides whose function is to transfer information at a selective interaction of the immune cells, nervous, endocrine and other systems. Under pathological conditions of the organism information transfer process is disrupted. What is happening as a result of this isolation and the accumulation of a number of endogenous compounds, including peptides, carrying a distorted information, prevents the coordinated work of the regulatory systems of the organism [6]. In this regard, the intake of physiologically active peptides promotes restoration of self organs and systems.

Physiologically active short peptides advisable to use as components of dietary supplements at any age to maintain a normal level of metabolism, prevention and treatment of various diseases, rehabilitation after serious illnesses, injuries, operations, slowing the aging process in the body [6].
Developed in the St. Petersburg Institute of Bio-regulation and Gerontology new high-technology spin-off from the organs and tissues of animals of low molecular weight peptide fractions allowed to create on their basis of a new class of biologically active additives - parapharmaceuticals, comprising 7 drugs and received a common name Tsitomaksy.
Ventfort® - a set of peptides derived from the vessels of young animals. The isolated peptides have a selective effect on various cells of the vascular wall, normalize metabolism in cells and regulate the function of the vascular system. In a clinical study set Ventforta® efficiency for complex reconstruction of functions of the vascular system after diseases of various origins, in pathological conditions leading to vascular dysfunction, exposure to extreme environmental factors, malnutrition, abuse lipid metabolism and aging.
Sigumir® - a set of peptides derived from cartilage and bone tissue of young animals. Selected peptides have a selective effect on different cells of cartilage and bone tissue, normalizes metabolism in cells and regulate the function of the joints and spine. In a clinical study of the effectiveness of installed Sigumira® for complex reconstruction of functions of the musculoskeletal system after diseases of various origins, in pathological conditions leading to dysfunction of cartilage and bone tissue, when exposed to extreme environmental factors, malnutrition, as well as aging.
Vladoniks® - a set of peptides derived from the thymus of young animals. The isolated peptides have a selective effect on various cells of the immune system, normalizes metabolism in cells and regulate the function of the immune system. In a clinical study of the effectiveness of installed Vladoniksa® for complex immune reconstitution after diseases of various origins, in pathological conditions leading to dysfunction of the immune system when exposed to extreme environmental factors, malnutrition, as well as aging.
Svetinorm® - a set of peptides derived from the liver of young animals. The isolated peptides have a selective effect on various hepatic cells, normalizes metabolism in cells and regulates liver function. In a clinical study of the effectiveness of Svetinorma® set for the integrated functions of the digestive system recovery after an illness of various origins, in pathological conditions leading to dysfunction of the gastrointestinal tract, when exposed to extreme environmental factors, malnutrition, abuse lipid metabolism and aging .
Tserluten® - a set of peptides derived from the brain of young animals. The isolated peptides have a selective effect on various cells of nervous tissue and brain, normalizes metabolism in cells and regulate their functions. In a clinical study of the effectiveness of installed Tserlutena® for comprehensive recovery of the central nervous system after diseases of various origins, in pathological conditions leading to disruption of brain function when exposed to extreme environmental factors, malnutrition, as well as aging.
Tireogen® - a set of peptides derived from the thyroid gland of young animals. The isolated peptides have a selective effect on various cells of the thyroid gland, normalizes metabolism in cells and regulates thyroid function. In a clinical study of the effectiveness of installed Tireogena® for comprehensive recovery of thyroid function after diseases of various origins, in pathological conditions leading to disruption of thyroid function when exposed to extreme environmental factors, malnutrition, when staying on the territory of endemic thyroid disease and aging.

Suprefort® - a set of peptides isolated from the pancreas of young animals. The isolated peptides have a selective effect on various cells of the pancreas, normalizes metabolism in cells and regulate pancreatic function. In a clinical study of the effectiveness of installed Supreforta® for comprehensive recovery of pancreatic function after diseases of the pancreas of various origins, in pathological conditions leading to violation of pancreatic function, exposure to extreme environmental factors, disorders of carbohydrate metabolism, malnutrition, as well as aging.
As a result of years of research at the St. Petersburg Institute of Bio-regulation and Gerontology has developed a new approach to the search for physiologically active peptides [7, 8]. Based on analysis of the amino acid sequence of polypeptides, extracted from animal organs and tissues, isolated short peptides formulation comprising 3-4 amino acids, which are "active site" of the drug based on extracts from the animal feed. It is possible to create a new class of biologically active additives - parapharmaceutics receiving Tsitogeny® common name that has no analogues in the world and includes the following products.
Vezugen® - peptide complex containing amino acids that contribute to the normalization of the functional state of vessels. In a clinical study set Vezugena efficacy in treatment of patients suffering from atherosclerosis of the heart, brain and lower limbs, disturbance of microcirculation in various organs and tissues, with psycho-emotional stress, as well as for the prevention of vascular disease in elderly and senile age.
Kartalaks® - peptide complex containing amino acids that contribute to normalize the function of cartilage tissue and musculoskeletal system. In a clinical study set Kartalaksa efficacy in treatment of patients suffering from spinal osteochondrosis, osteoarthritis, osteoporosis, after injuries and fractures, as well as in the prevention of sclerotic and degenerative processes in the spine and joints in people with middle and old age.
Kristagen® - peptide complex comprising an amino acid promoting the normalization of the function of the immune system. In a clinical study set Kristagena efficacy in treatment of patients with impaired immune system function after infectious diseases, radiation and chemotherapy, emotional stress and impact on the body of various unfavorable factors (including environmental, climatic, geo-pathogenic factors and ionizing radiation), as well as to maintain the function of the immune system in people with middle and old age.
Ovagen® - peptide complex comprising amino acids contributing to liver function normalization and gastrointestinal tract. In a clinical study Ovagena established its efficacy in treatment of patients suffering from hepatitis of various etiologies, in the prevention of complications of radiation or chemotherapy and the side effects of the use of antibiotics and other drugs, as well as the impacts on the body of various unfavorable factors (including environmental, toxic ), with malnutrition, as well as for maintaining liver function in people with middle and old age.
Pinealon® - peptide complex comprising an amino acid promoting the normalization of the functional activity of the brain cells. In a clinical study set Pinealona efficacy in treatment of patients with impaired brain function, including after a traumatic brain injury, stroke, surgical interventions on the brain, the impact on the body of extreme psycho-emotional factors as well as to maintain the mental health of persons of elderly and senile age. Pinealon improves intellectual functions of the brain (memory, attention, etc.) for persons whose professional activity requires a high concentration.
Honluten® - peptide complex comprising an amino acid promoting the normalization function of the lungs and bronchial mucosa. In a clinical study set Honlutena efficacy in treatment of patients with impaired lung function and bronchial acute and chronic respiratory diseases infectious and non-infectious origin, as well as to maintain the function of the respiratory system in elderly individuals.

The results of the clinical study of the efficacy of peptide bioregulators indicate whether they should be integrated application [5]. It is noteworthy that Tsitogeny act more quickly and have a narrow focus, because of their structure [3]. Influence Tsitomaksov manifested some time after the beginning of the course application, it is softer due to biological microenvironment associated peptide components that are part of these preparations. Due to the difference in the mechanism of action is the most efficient and cytogenetic Tsitomaksov their consistent course application: first appointed complex cytogenetic, and then - a complex Tsitomaksov.
Thus, it was shown that in case of violation of the cardiovascular system is most expedient to use complexes of several dietary supplements - first Vezugena, Ovagena and Kristagena and then - Ventforta, Svetinorma and Vladoniksa. This Vezugen Ventfort and optimize the state of the vascular wall, and Ovagen Svetinorm help improve lipid metabolism, and Kristagen and then Vladoniks performed maintenance of immune regulatory mechanisms of cardiovascular functions.
Correction of operations and maintenance of the central nervous system most effectively carried out with the purpose of complex cytogenetic and Tsitomaksov consisting, respectively, of Pinealona and Tserlutena that have a direct normalizing effect on the brain cells, Vezugena and then Ventforta restoring optimal blood supply to the brain, and Ovagena and Svetinorma further positively influence the lipid profile, which, in turn, contributes to the normalization of blood supply to the brain cells.
Important role in slowing the aging process in the body is given the proper functioning of the immune system, which contributes to consistent application and Kristagena Vladoniksa directly affecting the immune system cells, as well as Vezugena Ventforta and improving blood circulation in different organs and tissues.
Violation of the functions of the musculoskeletal system plays a critical role in the deterioration of the quality of life of elderly and senile age. Widespread in people of older age groups have degenerative-dystrophic diseases of joints and spine. In recent years, particular importance is the problem of osteoporosis, especially affecting women in the postmenopausal period. To help in solving these problems can only be a comprehensive approach. The results of our clinical studies indicate the need for long - at least 2 months - and the use of complex cytogenetic Tsitomaksov: first Kartalaksa Sigumira and that have a direct impact on the metabolism in the cells of cartilage and bone tissue; Vezugena and then Ventforta, reducing blood circulation and improves blood flow thereby cartilage and bone tissue, as well as further Kristagena Vladoniksa affecting the immune pathogenesis link to this group of diseases. Importantly, in the Sigumira includes minerals, including calcium and phosphorus, in a biologically bound form and optimum natural ratio, which ensures complete digestion of the body, so Sigumir is an essential component in a complex therapeutic interventions aimed at preventing and treating osteoporosis .

The development of age-related pathology in many ways by a variety of metabolic disorders. Timely preventive maintenance of carbohydrate metabolism disorders allows to delay or prevent the development of insulin-dependent diabetes mellitus, which is one of the most common diseases associated with aging. Many years of experience with Supreforta testifies to its high performance in the normalization of blood glucose levels for the prevention of type 2 diabetes in patients of older age groups, as well as in treatment of the disease with the use of glucose-lowering drugs, as Suprefort improves insulin sensitivity. The most stabilizing blood glucose levels can achieve in long-term (4-6 months) application Supreforta. In addition, it restores this drug metabolism in cells of the pancreas, preventing development of chronic pancreatitis and impaired pancreatic secretory function
Violation of lipid metabolism promotes the most common age-related diseases - atherosclerosis in elderly and senile age. This complex problem requires a comprehensive approach, which along with diet therapy requires the use of drugs that promote the normalization of the function of the digestive system, especially the liver. Based on the results of the clinical study and cytogenetic Tsitomaksov have reason to be recommended for this purpose a sequence of complex use of dietary supplements: first Ovagena and Vezugena that reduce metabolism in the liver cells and optimize the processes of lipid metabolism in the parietal vessels, respectively. And then it is advisable to appoint Svetinorma and Ventforta rate for the same purpose, and in addition - Supreforta normalizing the secretory function of the pancreas. The use of these drugs can act on different mechanisms of disorders of lipid metabolism and prevent the rapid progression of the atherosclerotic process in a variety of vessels. This complex also promotes correction of drug activity and maintaining the functions of the digestive system, since it provides the normalization of the liver and secretion of the pancreas.
Important role in improving the quality of life of elderly belongs to maintain thyroid function, the violation of which is the basis of many pathological conditions and diseases. Of particular importance, this problem becomes in areas of endemic disease hypothyroidism or hyperthyroidism. The results of clinical studies indicate that the course application Tireogena can improve the function of the thyroid-lezy same as indicated normalization of the content of the relevant hormones in the blood. Regular use Tireogena 2-3 times per year promotes maintenance of thyroid functions at an optimum level in humans of different age groups predisposed to the development of pathological processes in the thyroid gland.

Widespread diseases of broncho-pulmonary system, particularly among the elderly and senile age dictates the need to maintain the function of the bronchi and lungs to prevent respiratory diseases and improve the functions of the respiratory system. Clinical studies have shown that Honluten by acting on different structures of the bronchial mucosa epithelium, helping to reduce the incidence of respiratory infections, bronchitis, and also improves the function of the respiratory system in elderly people.
Long-term experience of clinical application of peptide bioregulators shows the need for the regular course of the appointment of various complexes of dietary supplements with an interval of 4-6 months to maintain the achieved level of metabolism in the cells of organs and tissues. This is confirmed by the experience of longitudinal clinical studies conducted at the Institute of Gerontology AMS Ukraine [2]. The authors present the results of long-term use of peptide bioregulators thymus and pineal gland in patients elderly courses 2 times a year, indicating that bioregulatory therapy contributes to the functional state of different organs and systems at an optimal level for the respective age groups.
Thus, now it opens the possibility for broad use in medicine natural peptides with the purpose of the regulation of various body functions. The most important area is the prophylactic use of peptide bioregulators to enhance the body's resistance to the effects of destabilizing factors. This will reduce the pace of aging, reduce the risk of developing age-related pathology, and helps to increase the period of active longevity and quality of life of elderly and senile age.

 

 

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