OUR PARTNERS

   

         

      

  

 

       

 

 

 

 

 

 

 

CONTACT US

PEPTIDES NPCRIZ STORE
HUNGARY
UKRAINE
shop(a)npcriz.co

DISCOUNTS

our price 31,50 EUR (34,34 USD)
In Stock
our price 25,00 EUR (27,25 USD)
In Stock
our price 17,50 EUR (19,08 USD)
In Stock

NEW ARTICLES

arr32020 Viorgons. Prevention and assistance with various diseases. Strokes, heart attacks, traumatic brain injuries (operations).If there is a violation of the... arr32019 Oligopeptides and the nuances of their use This article is devoted to oligopeptides and the nuances of their use. Very often, talking about... arr32019 Healthy Liver - Healthy Skin! You can ask banal questions:How often do you wash your face?Do you brush your teeth?Do you clean... arr32019 Peptides NPCRIZ: Effective Protection of the Liver and Pancreas    The human body works as a single, well-coordinated mechanism and any failure in the work of... arr32019 Anti-age complex NB Anti-AGE Complex NB: The Secret of Stellar Excellence   Friends! It is time for a pleasant... arr32019 NEW PRODUCT Nose Balms "RINOLAX" Nose Balms "RINOLAX"DESCRIPTIONBalsams "Cleansing" and "Regenerating" - innovative, effective... arr32018 Cardiovascular disease prevention September 29, worldwide, at the initiative of the World Heart Federation, with the support of many... arr32018 Previn and Peptide complex 19 - a complex for the prevention of cardiovascular diseases September 29 all over the world, at the initiative of the World Heart Federation, with the support... arr32018 Antitumor effect of peptides The modern period of development of medicine is characterized by significant achievements in the... arr32018 Trap for fat Customer feedback:"I learned about it from my brother, who lost about 7 kg with his help. His... arr32018 Zhenoluten and Endoluten - solving problems related to menopause Want to delay the onset of menopause and stay healthy for a long time? Do not neglect the latest... arr32018 Cytamins is a novel dietary supplements. Cytamins - are products for people who care about their health and appearance. Preservation of... arr32018 Why does not standard cosmetics help? Why does not standard cosmetics help?peptide cosmetics, peptides Any good, modern cream can... arr32018 How do peptides work for weight loss? Peptides are chains of proteins responsible for metabolic processes in our body, as well as for... arr32018 Create protection for immunityCreate protection for immunity   And although the window is still September with a gentle sun and... arr32018 Which peptides are the most important President of the Gerontological Society at the Russian Academy of Sciences, Doctor of Medical... arr32018 Revilab Peptide ML - a series of multifunctional AGE-protectors !  Youth and beauty have long been synonymous with the word "health". Today, many of us are... arr32017 Recovering the liver with peptides is extremely important in the fallRecovering the liver with peptides is extremely important in the fall. The aggravation of many... arr32017 Endoluten - treatment of human reproductive disordersRelationship between epiphysis cycles and human ageepiphysis The epiphysis (pineal body) is a small... arr32017 NEW Cosmetics RevilabNEW Cosmetics Revilab The company NPCRIZ constantly cares about its customers and fans of products.... arr32017 Revilab peptide SL ‒ innovation of the future!Modern consumers live in an accelerated pace, value their time and strive for a quick result. Each... arr32017 I was returned to life by peptides NPCRIZ "My name is Zhibek Aidarbekova. I am 58 years old. I live in Almaty, I am a retired police major,... arr32017 Nomination for the Nobel PrizeProfessor Chavinson wanted to extend the life of his parents. Russian Professor Vladimir Havinson... arr32017 Regenart: Joints under protection Diseases of the spine and joints are becoming an increasingly urgent problem in modern society. In... arr32017 What is diabetes?Diabetes and peptides, diabetes treatment. Diabetes is a chronic disease associated with a... arr32017 Why the standard of cosmetics does not help? Any good, modern cream can improve the appearance of the skin because it has moisturizing,... arr32017 The difference between peptides like GHRP-2 and GHRP-6 from Chavinson peptidesAll bodybuilders must read this article!Ghrp peptides A few years ago the world of bodybuilding was... arr32017 Peptides in bodybuildingHormones take a leading position among drugs to increase muscle mass, burn fat and increase stamina.... arr32017 Antitumor activity of peptides. Peptides and cancerThe modern period of development of medicine is characterized by significant achievements in the... arr32017 About therapy of patients with chronic prostatitisIn both scientific and popular editions devoted to the problem of chronic prostatitis, there is a... arr32017 So what is the uniqueness of the peptides NPCRIZ Today, scientists know that aging and disease of an organism begins at the moment when stops... arr32017 A cure for old ageAging is a biological process which in contrast to the time influenced. People have always tried to... arr32017 Research peptides NPCRIZThe deterioration of the peptide Bioregulation in the body reduces its resistance to destabilizing... arr32017 The secret of life is in the nano-peptidesGerontologists Experts say that in homo sapiens, like biological species, the life limit is 110-120... arr32017 The peptides NPCRIZ in sports and bodybuildingNatural peptides of SPB of Institute of Bioregulation and gerontology are widely used in... arr32016 PEPTIDE geroprotectors - prevention of agingSt. Petersburg Institute of Bio-regulation and Gerontology,Saint Petersburg A typical sign of aging... arr32016 A model of complementary interaction of short peptides with the DNA double helixComparison of the spatial arrangement of functional groups of the nucleic bases on the surface of... arr32016 Peptides in cosmeticsPeptides can include not only medicines, but also in other products. For example, Russian scientists... arr32016 Why is all shown interest in peptide bioregulators? The interest on the part of scientists, doctors, beauty industry professionals, and ordinary... arr32016 Peptides NPCRIZ for the prevention and treatment of Zika VirusIn today's time when the world is attacked by new diseases, such as Zik Virus , the NPCRIZ company... arr32016 Serum for skin around the eyes №5Serum for skin around the eyes №5 green BeautifeyeTM and horse chestnut seed extract are directed... arr32016 WHAT IS REVITALIZATION ?Revitalization is a new direction in medicine, designed to facilitate the restoration, or rather,... arr32016 New products 2016  The range of natural peptide bioregulators added another novelty - geroprotector " Bonomarlot... arr32015 NEW Citomax-GlandokortThe complex of peptide fractions obtained from adrenal young animals. The isolated peptides have a...

MOST POPULAR

our price 70,00 EUR (76,30 USD)
In Stock
our price 18,20 EUR (19,84 USD)
Out of Stock
our price 92,00 EUR (100,28 USD)
In Stock



CLINICAL STUDY OF SUPREFORT

The dietary supplement Suprefort is a complex of low-molecular peptides with molecular weight up to 5000 Da, isolated from pancreas of young animals - calves aged up to 12 months. Isolated peptides possess tissue-specific action to pancreas cell tissue, thus restoring metabolism and normalizing its functional activity.

Suprefort is manufactured in the form of capsules, containing 10 mg of active peptides. Suprefort was administered per os 10-15 minutes before meal 1-2 capsules 2 times a day for 10-20 days depending on severity of the pathological process. 

The clinical studies of Suprefort were carried out at the Medical Center of the Saint Petersburg Institute of Bioregulation and Gerontology in patients with Chronic pancreatitis in the state of remission and in patients with Diabetes mellitus II during the period from November 2005 till January 2006.

Deregulation of physiological functions and pathological changes in pancreas result in diseases with signs of nutrition and metabolism disorders. Consequences of progressive inflammatory process in pancreas are, as a rule, dystrophic processes accompanied with disorders of excretion of digestive pancreatic enzymes, characteristic for chronic pancreatitis.  In the presence of disorders of insulin secretion, the patient has symptoms of ‘secondary’ diabetes mellitus.

Diabetes mellitus is one of most widespread endocrine diseases: about 1-2% of Earth’s population has it. Besides there are same amount of people with occult diabetes and genetically predisposed to this disease. The diabetes signs in any single case are integrated reaction to mutual action of multiple factors with various combinations (genetic predisposition, chemical and infectious agents of environment, autoimmune processes, nutrition, physical activity, psychological stresses etc.). Detection of new syndromes (diabetes, caused by formation of antibodies to insulin receptors; diabetes caused by genetic defects of insulin structure etc.) is a reason of constant necessity of addition of disease classification. Potential, latent and asymptomatic forms of the diseases without clinical symptoms require special attention concerning prognosis, prophylaxis and treatment (1, 3, 6, 7, 8). Treatment of chronic pancreatitis is based mainly on diet and enzyme preparations (pancreatin, pansinorm) etc. (5) Treatment of diabetes mellitus without clinical signs requires diet therapy and phytotherapy (2, 4).

Clinical characteristic of the patients
Distribution of the patients by diagnoses, sex and age is shown in the table 1. Treatment using Suprefort was carried out in 34 patients (18 male and 16 female) with diagnoses ‘Chronic pancreatitis, latent form’ (12 persons) and ‘Diabetes mellitus II type, latent form’ (22 persons). The patients with chronic pancreatitis were complaining of the loss of appetite, eructation, meteorism, borborygmus, stool disorders. Two groups of patients were formed using random sampling technique, in these groups the patients have similar sex, age and diagnosis: the basic group included 12 patients (8 men, 4 women), control group - 8 patients (4 men, 4 women).

Table 1
Distribution of the patients by diagnosis, sex and age

 

The patients of the control group have been taking general purpose medicines. The patients of the main group have been taking Suprefort in addition to the general purpose medicines - 1-2 capsules, 2 times a day before meal for 15 days.
Diabetes mellitus II in the patients was not accompanied by any clinical signs and was diagnosed on the basis of an increase in glucose level in peripheral blood in view of unbalanced diet.
Control group included 17 patients, who have been taking general purpose medicines. 22 patients of the main group have also been taking Suprefort in addition to the general purpose medicines - 1 capsule, 2 times a day before meal for 15 days.

Examination methods 
The patient complaints were assessed and compared, general clinical studies of blood and urine were carried out together with blood biochemical test using ‘REFLOTRON’ device, (Boehringer Mannheim, Germany). Duodenal content was examined. Glucose tolerance test was carries out. 

Examination results
It was established that administration of Suprefort in patients with chronic pancreatitis resulted in increase in appetite and decrease in the rate of dyspepsia.

Table 2 
Suprefort influence of activity of digestive enzymes in patients  with chronic pancreatitis

 

Laboratory assessment of duodenal content has shown initial decrease in activity of pancreatic enzymes (table 2). After Suprefort administration there is tendency toward increase in activity of pancreatic enzymes, which correlated with improved clinical symptoms.

Suprefort in patients with diabetes mellitus II was administered in parallel with glucose tolerance test. It was established that after glucose challenge the patients had characteristic glycemic curve. The patients of the main group have also been taking Suprefort in addition to the general purpose medicines - 1 capsule, 2 times a day before meal for 10 days. It was shown, that after Suprefort administration the test carried out in 2 hours after beginning of the study showed gradual decrease in the glucose level. In 5-10 days after beginning of the treatment course the patients had normal glucose levels. None of the patients had increased dosage of blood glucose lowering drugs, 12 patients (54,5%) were using decreased levels of general purpose medicines and in 7 patients (31,8%) the blood glucose level was below normal values without blood glucose lowering drugs. In 3 patients (13,6%) the parameters remained at the initial level. It is worth noting the stabilization of the blood glucose parameter in the patients of the main group within next 2-3 month after the end of treatment (table 3).

Table 3
Suprefort influence on blood glucose values after glucose loading in patients with diabetes mellitus II

 

In patients of the control group, who have been taking general purpose blood glucose lowering drugs, it was not possible to lower the dosage of the medicines, and in 9 patients (52,9%) the dosage of blood glucose lowering drugs was increased with a purpose of normalization of content of blood glucose.
Thus the results of the clinical study obtained confirm an efficiency of Suprefort and expediency of its use in complex treatment of the patients with chronic pancreatitis and diabetes mellitus II.

Suprefort does not result in side effects, complications and drug dependence. Suprefort is convenient for administration in hospital, out-patient conditions and at home. Suprefort can be used as medical and preventive mean in the form of biological active food additive and in the form of adjunct in combination with any means of symptomatic and pathogenetic therapy, used for treatment of patients with chronic pancreatitis and other diabetes mellitus II.

Conclusion
The dietary supplement Suprefort normalizes functional activity of pancreas cells. 
Suprefort is well tolerated by patients at oral administration; it does not result in any side effects and can be widely used as a treatment and prophylactic biologically active food additive for complex treatment of pancreatic function disorders.

Recommended Suprefort dosage
In patients with chronic pancreatitis - per os 10-15 minutes before meal 1-2 capsules, 2 times a day for 15 days.
In patients with diabetes mellitus - per os 10-15 minutes before meal 1 capsule, 2 times a day for 15 days in parallel with blood glucose monitoring.
It is expedient to carry out another treatment course in 3-6 month if needed.

References
1.Balabolkin M.I. Diabetes mellitus / Endocrine disorders // Diagnostics and treatment of internal diseases: Manual for doctors. - Edited by F.I.Komarova. - M.: Medicine, 1991. - V. 2. - pages 465-492.
2. Belousov Y.B., Moiseev V.S., Lepakhin V.K. Clinical pharmacology and pharmacotherapy: Manual for doctors. - M.: Universum, 1993. - 398 pages
3. Internal diseases / Edited by A.S. Smetnev, V.G. Kukes. - M.: Medicine, 1982. - 496 pages
4. Yordanov D., Nikolov P., Boychinov Asp. Phytotherapy. - Sofia: Medicine and physical culture, 1972. -  346 pages
5. Mashkovsky M.D. Medicines: Pharmacotherapy for doctors, manual: 2 parts. - Vilnius: ZAO “Gamta”, 1993.
6. Geriatry manual / Edited by D.F. Chebotarev, N.B. Mankovsky. - M.: Medicine, 1982. - 544 pages
7. Teppermen G., Teppermen H.  Physiology of metabolism and endocrine system: Translated from English. - M.: Mir, 1989. -  656 pages
8. Ugolev A.M., Radbil O.S. Digestive system hormones. - M.: Nauka, 1995. - 283 pagesDiabetes mellitusDiabetes mellitusDiabetes mellitusDiabetes mellitusDiabetes_mellitusDiabetes_mellitus

 

ZGMyYTM3Z