The Saint Petersburg Institute of Bioregulation and Gerontology (SPIBG) of the North-Western Branch of the Russian Academy of Medical Sciences for years has been developing a special approach to a new class of peptide-based supplements. As a result of the analysis of the amino-acidic sequence of peptides extracted from organs and tissues, physiologically active short peptides have been developed and later defined as a class of citogenes, also known as the synthesized short peptides. This class of dietary supplements is characterized by a faster action compared to extracts: the physiological effects become evident after 24 hours, the main processes related to regulating work and functionality of organs and systems are launched. It is therefore considered highly important to take these synthesized peptides in the earliest stage of biotherapy.
On the other hand, the extracted peptides, widely known as the citomax class, or the natural peptides, perform in a more delicate and gradual manner due to their so called specific physiological environment: it includes amino acids and microelements typical for that type of tissue from which they have been extracted in terms of quantity and quality. As a consequence of discrepancy in performance and effects of the different classes of peptides (synthesized or natural), SPIBG recommends their step-wise use as more reasonable. For instance, in the first four weeks a course of synthesized peptides can be taken, followed by one to two months of biotherapy based on natural peptides.