NRE -4 - NEW GENERATION biogenic amines OUTDOOR MESOTHERAPY
NRE -4 ( TNRE - tetrahydroxypropyl ethylenediamine) by its very nature is derived widespread in aesthetic medicine and cosmetology precursor of acetylcholine - deanol .Acetylcholine precursors when used topically bind to the corresponding receptors on the skin cells ( fibroblasts , keratinocytes ) and lead to a change in the texture of the skin.HPE -4 belongs to the same group of substances being dual deanol molecule (composed of 2- amine ).
In studies revealed that NRE -4 almost four times more deanol , and twice as many volunteers are sensitive to it. This was reflected in the fact that the number of women responded positively to the anti-aging NRE -4 ( smoothing fine wrinkles and wrinkles , improve skin tone and texture ) was greater and its anti-aging effect was more pronounced . Hence, the NRE -4 is much more functional compound than deanol.
Microscopy clearly observed result of the interaction of keratinocytes with NRE -4 , which is manifested in the reduction of the area of the latter, and thereby develops a lifting effect . Preclinical efficacy testing NRE -4 conducted not only abroad , but also in Russia , were based on the measurement of the electrical resistance of keratinocytes. It is known that the performance of their area are inversely proportional to the resistance ; ie more cells in the volume , the lower the resistance . Mortar NRE -4 leads to a reduction in the area of keratinocyte growth and resistance. Increasing concentrations of NRE -4 leads to even higher resistance and , therefore, a more pronounced reduction in the area of keratinocytes and increased lifting effect . Consequently, for typical NRE -4 dose-dependent effect is especially important in the preparation of cosmetic compositions of a different orientation.
The second important aspect of action NRE -4 due to the influence on the function of fibroblasts that in response to its application increase the level of collagen and elastin synthesis . Direct consequence of this is to increase the elasticity of the skin.
Certainly, every new cosmetics market goes a long way from becoming design to implementation . Historically, that NRE -4 is used worldwide for more than 20 years and is in very small concentrations as a neutralizer of acidic substances found in many products for skin care and hair (for both adults and children). However, only a focused study of its effects in the past few years has revealed excellent anti-aging properties of HPE -4 , as well as to confirm its softness and tolerability of a wide dose range.
Safety NRE -4 has been repeatedly proven in laboratory animals as well as on volunteers . Compositions containing various concentrations of drug for 6 months systematically applied to various areas of the body and, thus , do not cause irritation , sensitization and allergic reactions. Moreover , NRE -4 is absolutely safe when applied to the eye , which was also confirmed clinically.
Neovitin ®- inducer of endogenous superoxide dismutase.
Neovitin ® - a product with strong antioxidant and anti-aging properties, derived from the ginseng root biomass on the original technology CBW at RAS "VITA ". Designed complex has undergone the required experimental studies at the Institute of Toxicology. Proved its anti-inflammatory, UV- a protective, regenerirueschee, antimicrobial, immunomodulatory and antitumor action. It also improves skin turgor and local skin blood flow.
Many biochemical reactions in the body flow through a free radical mechanism, but the influence of the environment and failures own antioxidant system lead to accumulation of excess free radicals. As a result, the body undergoes oxidative stress. As modern vysokodeystvennogo anti-oxidative agents in the modern pharmaceutical industry have long used the biomass of ginseng cells, cultivated using a proprietary biotechnology. The fact that the activity of ginseng significantly higher biomass than living roots. The process of growing biomass technologically and enables a large number of environmentally friendly raw materials, in modern conditions is important. The drug, derived from biomass ginseng root on original technology, provides antioxidant protection by stimulating the production of endogenous superoxide dismutase - one of the major antioxidant systems.
Effect of the active components of the complex accelerates the production of enzymes in the body antioksidatnyh and interferon , which inhibits the reaction of peroxide oxidation (breakdown ) of cell membrane lipids, strengthen them and, thereby, increase the resistance of tissues and inhibit premature aging.
Unique anti-inflammatory and regenerative properties Neovitin ® confirmed 11 patents for inventions and awarded gold medals RANS them. II Mechnikov "For practical contribution to improving the health of the nation" and Paul Ehrlich European Commission's academic awards " for special merits in the field of social and preventive medicine."
NRE -4 + Neovitin
Despite the fact that the central figure in an outer mesothelium is a drug NRE -4 today impossible to imagine its use as a means of mono . Therefore , in order to influence the maximum possible number of links in the pathogenesis of premature skin aging , we proposed to use an outer mesothelium as anti-aging complex is a combination of NRE -4 and Neovitin ®. On the one hand, Neovitin ® serves here as a booster ( amplifier effect) that proved clinically ( NRE - efficiency increased by 23 4 %). On the other hand , the drug improves microcirculation of the skin , increases the antioxidant status of the skin and prevents photoaging . In this aspect, the complex NRE -4 + Neovitin ® should be considered as the best combination of high-level components of an outer mesothelium , providing maximum expression of this class of drugs for anti-aging effect.
In the outer mesothelium based complex NRE -4 + ® Neovitin laid a number of high-level ingredients and extracts that allow them to work purposefully and effectively on their respective areas of the skin.
In the outer mesothelium body uses lactic and succinic acid . It is a cellular energy, biochemical and optimizes energy metabolism in cells and significantly slows the aging of skin. The result of this action is to improve the color and texture of the skin. In addition, in the mesothelium body contains active extracts of horsetail , Aralia and artichoke .In combination with panthenol they stimulate blood circulation in the skin ; have anti-inflammatory and antioxidant effects ; protect the membranes of skin cells from damage ;increase the intensity of the flow of metabolic processes , contributing to faster burning and disposal of fat in the subcutaneous fat ; increase skin elasticity and reduces the appearance of the so-called orange peel.
Apply a small amount of the liquid in the evening on a previously cleansed body areas and rub in with massage movements until the substance is completely absorbed. Apply daily. Course duration - 3 months.
Purified water, tetrahydroxypropyl propylene, bio-antioxidant complex "Neovitin» ®, lactic acid, glycerin, phenoxyethanol with ethylhexylglycerin extract, horsetail extract, Aralia, artichoke extract, panthenol, succinic acid, sodium carboxymethylcellulose, Perfume, PEG-40 hydrogenated castor oil, Trilon B.